Casey Jones is highly potent, and its sativa genes create a strong, energetic head high that spurs creativity – and maybe a little daring. The taste is citrusy and sweet, with earthy undertones. Casey Jones is best for anxiety and depression, as it provides a powerful mood boost. It's also helpful in treating pain and low energy. Casey Jones, a cross between Oriental Express and East Coast Sour Diesel, is most popular in Amsterdam, Michigan, and the West Coast.